Selection of human immunodeficiency virus type 1 R5 variants with augmented replicative capacity and reduced sensitivity to entry inhibitors during severe immunodeficiency.

@article{Repits2005SelectionOH,
  title={Selection of human immunodeficiency virus type 1 R5 variants with augmented replicative capacity and reduced sensitivity to entry inhibitors during severe immunodeficiency.},
  author={Johanna Repits and Monica Oberg and Joakim Esbj{\"o}rnsson and Patrik Medstrand and Anders Karlsson and Jan Albert and Eva M{\'a}ria Feny{\"o} and Marianne Jansson},
  journal={The Journal of general virology},
  year={2005},
  volume={86 Pt 10},
  pages={2859-69}
}
Early in human immunodeficiency virus 1 (HIV-1) infection CCR5-using (R5) viruses predominate. With disease progression, approximately 50% of infected individuals develop viruses able to use CXCR4. In the present work, the evolution of the biological properties of HIV-1 was studied in patients who retain viruses with an R5 phenotype despite AIDS onset. A panel of primary R5 HIV-1 isolates sequentially obtained at an asymptomatic stage and after AIDS diagnosis was examined. The viruses were… CONTINUE READING

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