Selection of heterogeneous vancomycin-intermediate Staphylococcus aureus by imipenem.

  title={Selection of heterogeneous vancomycin-intermediate Staphylococcus aureus by imipenem.},
  author={Yuki Katayama and Hiroko Murakami-Kuroda and Longzhu Cui and Keiichi Hiramatsu},
  journal={Antimicrobial agents and chemotherapy},
  volume={53 8},
Vancomycin (VAN)-intermediate Staphylococcus aureus (VISA) and heterogeneous VISA (hVISA) isolates are considered to have emerged from VAN-susceptible S. aureus (VSSA) by spontaneous mutation during VAN exposure. We previously reported that laboratory mutant H14, obtained from VSSA strain Delta IP by exposure to imipenem (IPM), showed overexpression of the vraSR two-component system and a typical hVISA phenotype. In the present study, to elucidate the mechanism of VSSA conversion to hVISA, we… CONTINUE READING


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