Selection of hepatitis B virus polymerase mutants with enhanced replication by lamivudine treatment after liver transplantation.

Abstract

BACKGROUND & AIMS Lamivudine has become a main therapeutic option for treating hepatitis B virus (HBV) infection. Although drug resistance develops, the clinical course after selection of antiviral-resistant HBV mutants seems to be benign. However, we observed a severe clinical course of hepatitis B infection in several liver transplant recipients after the… (More)

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