Selection of experimental conditions for the accurate determination of blood--brain transfer constants from single-time experiments: a theoretical analysis.

@article{Blasberg1983SelectionOE,
  title={Selection of experimental conditions for the accurate determination of blood--brain transfer constants from single-time experiments: a theoretical analysis.},
  author={Ronald G. Blasberg and Clifford S. Patlak and Joseph D. Fenstermacher},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={1983},
  volume={3 2},
  pages={
          215-25
        }
}
Reliable blood-brain transfer constants can be determined from data obtained in single-time experiments (i.e., a single experimental time for tissue sampling). The accuracy of such measurements depends on factors such as the test molecule used and the experimental time chosen; therefore, the selection of optimal experimental conditions is important. In this presentation, a model of transport across the blood--brain barrier (BBB) was developed and used to determine appropriate experimental… CONTINUE READING
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