Selection of endometrial carcinomas for DNA mismatch repair protein immunohistochemistry using patient age and tumor morphology enhances detection of mismatch repair abnormalities.

@article{Garg2009SelectionOE,
  title={Selection of endometrial carcinomas for DNA mismatch repair protein immunohistochemistry using patient age and tumor morphology enhances detection of mismatch repair abnormalities.},
  author={Karuna Garg and Mario M M Leitao and Noah D. Kauff and Jessica R Hansen and Kristi Kosarin and Jinru Shia and Robert A Soslow},
  journal={The American journal of surgical pathology},
  year={2009},
  volume={33 6},
  pages={925-33}
}
Women with hereditary nonpolyposis colorectal cancer (HNPCC) have a high risk for endometrial cancer (EC) and frequently present with a gynecologic cancer as their first or sentinel malignancy. Identification of these patients is important given their personal and family risk for synchronous and metachronous tumors. The revised Bethesda Guidelines provide screening criteria for HNPCC in colorectal cancers. However, there are currently no such screening recommendations for women with endometrial… CONTINUE READING

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