Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis.

@article{Castresana2000SelectionOC,
  title={Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis.},
  author={Jose Castresana},
  journal={Molecular biology and evolution},
  year={2000},
  volume={17 4},
  pages={
          540-52
        }
}
  • J. Castresana
  • Published 2000
  • Biology, Medicine
  • Molecular biology and evolution
The use of some multiple-sequence alignments in phylogenetic analysis, particularly those that are not very well conserved, requires the elimination of poorly aligned positions and divergent regions, since they may not be homologous or may have been saturated by multiple substitutions. A computerized method that eliminates such positions and at the same time tries to minimize the loss of informative sites is presented here. The method is based on the selection of blocks of positions that… Expand
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