Selection of a moxifloxacin dose that suppresses drug resistance in Mycobacterium tuberculosis, by use of an in vitro pharmacodynamic infection model and mathematical modeling.

@article{Gumbo2004SelectionOA,
  title={Selection of a moxifloxacin dose that suppresses drug resistance in Mycobacterium tuberculosis, by use of an in vitro pharmacodynamic infection model and mathematical modeling.},
  author={Tawanda Gumbo and Arnold Louie and Mark R. Deziel and Linda M Parsons and Max Salfinger and George L. Drusano},
  journal={The Journal of infectious diseases},
  year={2004},
  volume={190 9},
  pages={1642-51}
}
BACKGROUND Moxifloxacin is a quinolone antimicrobial that has potent activity against Mycobacterium tuberculosis. To optimize moxifloxacin dose and dose regimen, pharmacodynamic antibiotic-exposure targets associated with maximal microbial kill and complete suppression of drug resistance in M. tuberculosis must be identified. METHODS We used a novel in vitro pharmacodynamic infection model of tuberculosis in which we exposed M. tuberculosis to moxifloxacin with a pharmacokinetic half-life of… CONTINUE READING
103 Citations
49 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 103 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Similar Papers

Loading similar papers…