Selection of a model and estimation of principal pharmacokinetic parameters of dioxadet

Abstract

Only one single paper is known [7] on the investigation of the pharmacokinetics of aziridine derivatives of sym-triazine, whichinclude the antitumorigenic compound dioxadet [I, 2]. The investigation was carried out by the para-nitrobenylpyrimidine method for determining active groups of alkylating compounds, which is only slightly sensitive. Thus, only a general idea was obtained on the behavior of dioxadet in the animal organism; the pharmacokinetic parameters were not calculated.

DOI: 10.1007/BF00767166

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Cite this paper

@article{Korsakov2004SelectionOA, title={Selection of a model and estimation of principal pharmacokinetic parameters of dioxadet}, author={M. V. Korsakov and V. A. Filov and Boris Kraiz and T. N. Khrapova and Boris A. Ivin}, journal={Pharmaceutical Chemistry Journal}, year={2004}, volume={19}, pages={667-671} }