Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malaria.

@article{Happi2009SelectionOP,
  title={Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malaria.},
  author={Christian Tientcha Happi and Grace Olusola Gbotosho and Onikepe Abiola Folarin and A. Sowunmi and Thomas Hudson and Michael O'Neil and Wilbur K. Milhous and Dyann F Wirth and Ayoade M. J. Oduola},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 3},
  pages={888-95}
}
We assessed Plasmodium falciparum mdr1 (Pfmdr1) gene polymorphisms and copy numbers as well as P. falciparum Ca(2+) ATPase (PfATPase6) gene polymorphisms in 90 Nigerian children presenting with uncomplicated falciparum malaria and enrolled in a study of the efficacy of artemether-lumefantrine (AL). The nested PCR-restriction fragment length polymorphism and the quantitative real-time PCR methodologies were used to determine the alleles of the Pfmdr1 and PfATPase6 genes and the Pfmdr1 copy… CONTINUE READING

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