Selection of Intracellular Single-Domain Antibodies Targeting the HIV-1 Vpr Protein by Cytoplasmic Yeast Two-Hybrid System

@inproceedings{Matz2014SelectionOI,
  title={Selection of Intracellular Single-Domain Antibodies Targeting the HIV-1 Vpr Protein by Cytoplasmic Yeast Two-Hybrid System},
  author={Julie Matz and C{\'e}cile H{\'e}rate and J{\'e}r{\^o}me Bouchet and Nelson Dusetti and Odile Gayet and Daniel Baty and Serge B{\'e}nichou and Patrick Chames},
  booktitle={PloS one},
  year={2014}
}
The targeting of HIV-1 using antibodies is of high interest as molecular tools to better understand the biology of the virus or as a first step toward the design of new inhibitors targeting critical viral intracellular proteins. Small and highly stable llama-derived single-domain antibodies can often be functionally expressed as intracellular antibodies in the cytoplasm of eukaryotic cells. Using a selection method based on the Sos Recruitment System, a cytoplasmic yeast two-hybrid approach, we… CONTINUE READING
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