Selection of HIV-specific immunogenic epitopes by screening random peptide libraries with HIV-1-positive sera.

@article{Scala1999SelectionOH,
  title={Selection of HIV-specific immunogenic epitopes by screening random peptide libraries with HIV-1-positive sera.},
  author={Giuseppe Scala and Xueni Chen and Wei-feng Liu and J N Telles and Oren Cohen and Mauro Vaccarezza and Tatsuhiko Igarashi and Anthony S. Fauci},
  journal={Journal of immunology},
  year={1999},
  volume={162 10},
  pages={6155-61}
}
Efforts to develop a protective HIV-1 vaccine have been hindered by difficulties in identifying epitopes capable of inducing broad neutralizing Ab responses. In fact, the high mutation rate occurring in HIV-1 envelope proteins and the complex structure of gp120 as an oligomer associated with gp41 result in a high degree of antigenic polymorphism. To overcome these obstacles, we screened random peptide libraries using sera from HIV-infected subjects to identify antigenic and immunogenic mimics… CONTINUE READING

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