Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

@article{Aschenbrenner2007SelectionOF,
  title={Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells},
  author={Katharina Aschenbrenner and Louise M D'Cruz and Elisabeth H. Vollmann and Maria Hinterberger and Jan Emmerich and Lee Kim Swee and Antonius G. Rolink and Ludger Klein},
  journal={Nature Immunology},
  year={2007},
  volume={8},
  pages={351-358}
}
The parameters specifying whether autoreactive CD4+ thymocytes are deleted (recessive tolerance) or differentiate into regulatory T cells (dominant tolerance) remain unresolved. Dendritic cells directly delete thymocytes, partly through cross-presentation of peripheral antigens 'promiscuously' expressed in medullary thymic epithelial cells (mTECs) positive for the autoimmune regulator Aire. It is unclear if and how mTECs themselves act as antigen-presenting cells during tolerance induction… CONTINUE READING
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