Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma

@article{Zhang2013SelectionOB,
  title={Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma},
  author={Xiang H.-F. Zhang and Xin Jin and S. B. Malladi and Yilong Zou and Yong Hannah Wen and Edi Brogi and Marcel Smid and John A. Foekens and Joan Massagu{\'e}},
  journal={Cell},
  year={2013},
  volume={154},
  pages={1060-1073}
}
How organ-specific metastatic traits arise in primary tumors remains unknown. Here, we show a role of the breast tumor stroma in selecting cancer cells that are primed for metastasis in bone. Cancer-associated fibroblasts (CAFs) in triple-negative (TN) breast tumors skew heterogeneous cancer cell populations toward a predominance of clones that thrive on the CAF-derived factors CXCL12 and IGF1. Limiting concentrations of these factors select for cancer cells with high Src activity, a known… CONTINUE READING
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