Selection in favor of nucleotides G and C diversifies evolution rates and levels of polymorphism at mammalian synonymous sites.

@article{Kondrashov2006SelectionIF,
  title={Selection in favor of nucleotides G and C diversifies evolution rates and levels of polymorphism at mammalian synonymous sites.},
  author={Fyodor A. Kondrashov and Aleksey Y. Ogurtsov and Alexey S. Kondrashov},
  journal={Journal of theoretical biology},
  year={2006},
  volume={240 4},
  pages={616-26}
}
The impact of synonymous nucleotide substitutions on fitness in mammals remains controversial. Despite some indications of selective constraint, synonymous sites are often assumed to be neutral, and the rate of their evolution is used as a proxy for mutation rate. We subdivide all sites into four classes in terms of the mutable CpG context, nonCpG, postC, preG, and postCpreG, and compare four-fold synonymous sites and intron sites residing outside transposable elements. The distribution of the… CONTINUE READING

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