Selection for simple major surface protein 2 variants during Anaplasma marginale transmission to immunologically naïve animals.

@article{Palmer2007SelectionFS,
  title={Selection for simple major surface protein 2 variants during Anaplasma marginale transmission to immunologically na{\"i}ve animals.},
  author={Guy H. Palmer and James E. Futse and Christina K. Leverich and Donald P. Knowles and Fred R. Rurangirwa and Kelly A. Brayton},
  journal={Infection and immunity},
  year={2007},
  volume={75 3},
  pages={1502-6}
}
Anaplasma marginale, a rickettsial pathogen, evades clearance in the animal host by antigenic variation. Under immune selection, A. marginale expresses complex major surface protein 2 mosaics, derived from multiple donor sequences. However, these mosaics have a selective advantage only in the presence of adaptive immunity and are rapidly replaced by simple variants following transmission.