Selection for short introns in highly expressed genes

  title={Selection for short introns in highly expressed genes},
  author={Cristian I. Castillo-Davis and S. Mekhedov and D. Hartl and E. Koonin and F. Kondrashov},
  journal={Nature Genetics},
  • Cristian I. Castillo-Davis, S. Mekhedov, +2 authors F. Kondrashov
  • Published 2002
  • Biology, Medicine
  • Nature Genetics
  • Transcription is a slow and expensive process: in eukaryotes, approximately 20 nucleotides can be transcribed per second at the expense of at least two ATP molecules per nucleotide. Thus, at least for highly expressed genes, transcription of long introns, which are particularly common in mammals, is costly. Using data on the expression of genes that encode proteins in Caenorhabditis elegans and Homo sapiens, we show that introns in highly expressed genes are substantially shorter than those in… CONTINUE READING
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