Selection for contextual fear conditioning affects anxiety-like behaviors and gene expression.

@article{Ponder2007SelectionFC,
  title={Selection for contextual fear conditioning affects anxiety-like behaviors and gene expression.},
  author={Christine A. Ponder and Christopher L. Kliethermes and Michael R Drew and Jeffrey Muller and Kiranmoy Das and Victoria B Risbrough and J Christopher F Crabbe and Thomas Conrad Gilliam and Abraham A Palmer},
  journal={Genes, brain, and behavior},
  year={2007},
  volume={6 8},
  pages={736-49}
}
Conditioned fear and anxiety-like behaviors have many similarities at the neuroanatomical and pharmacological levels, but their genetic relationship is less well defined. We used short-term selection for contextual fear conditioning (FC) to produce outbred mouse lines with robust genetic differences in FC. The high and low selected lines showed differences in fear learning that were stable across various training parameters and were not secondary to differences in sensitivity to the… CONTINUE READING

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