Selection for carriers of recessive diseases: a common phenomenon?

Abstract

Several autosomal recessive disorders are present in high frequency in isolated populations because of either multiple allelic mutations or mutations in different genes. These observations are best explained by selection, which may be an important mechanism in the determination of the distribution of genetic disorders. 

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Cite this paper

@article{Zlotogora1998SelectionFC, title={Selection for carriers of recessive diseases: a common phenomenon?}, author={Jo{\"e}l Zlotogora}, journal={American journal of medical genetics}, year={1998}, volume={80 3}, pages={266-8} }