Selection dynamics in autocatalytic systems: templates replicating through binary ligation.

  title={Selection dynamics in autocatalytic systems: templates replicating through binary ligation.},
  author={Peter R. Wills and Stuart A. Kauffman and Beda M. Stadler and Peter F. Stadler},
  journal={Bulletin of mathematical biology},
  volume={60 6},
The theory of autocatalytic binary ligation is reviewed within the context of a consistently applied Michaelis-Menten quasi-steady-state approximation to obtain explicit analytical results describing time-course data from experiments. A detailed protocol for the step-wise elucidation of a minimal set of experimental parameters is outlined. The kinetic equations are then generalized to cases of self- and cross-catalysis among an arbitrary number of different templates and applied to experiments… CONTINUE READING

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