Selection criteria for human embryo transfer: A comparison of pyruvate uptake and morphology

  title={Selection criteria for human embryo transfer: A comparison of pyruvate uptake and morphology},
  author={Joe Conaghan and Kate Hardy and Alan H. Handyside and Robert M. L. Winston and Henry J. Leese},
  journal={Journal of Assisted Reproduction and Genetics},
Pyruvate uptake is higher in human embryos developing to the blastocyst stage than those arresting at cleavage stages. To investigate whether pyruvate uptake provides an improved criterion for selecting embryos for transfer, we have measured uptakes by individual embryos noninvasively over 24-hr periods between the first day (day 1) postinsemination and embryo transfer on day 2 or 3 and correlated the levels with implantation and pregnancy outcome. The mean uptake was significantly lower for… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 44 references

Development of human blastocysts in vitro

  • K Hardy
  • Lancet
  • 1993
2 Excerpts

Factors affecting success at the time of embryo transfer

  • K Dawson, RA Margara, SG Hillier, D Packham, N Winston, Winston RML
  • Preimplantation Embryo Development , B Bavister…
  • 1993

KGMM: Optimized methods to measure acetoacetate, 3-hydroxybutyrate, glycerol, alanine, pyruvate, lactate and gluJournal o f Assisted Reproduction and Genetics

  • R Stappenbeck, AW Hodson, AW Skillen, L Agius, Alberti
  • J Automatic Chem
  • 1993
1 Excerpt

Can non-invasive measurement of pyruvate uptake in culture assist embryo selection for transfer following in-vitro fertilization

  • J Conaghan, K Martin, +4 authors HJ Leese
  • J Obstet Gynaecol
  • 1991
2 Excerpts

Metabolism of the preimplantation embryo

  • H JLeese
  • Oxford Rev Reprod Biol
  • 1991
1 Excerpt

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