Selection bias: maintaining less-differentiated T cells for adoptive immunotherapy.

Abstract

The clinical application of T cell immunotherapy depends on ex vivo modification and expansion of T cells for adoptive transfer. In preclinical models, the use of a purified, naive T cell subset enhances persistence and antitumor immunity; however, the majority of clinical studies rely on modification of mixed populations of T cells that contain only a… (More)
DOI: 10.1172/JCI85631

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