Selection and reduced population size cannot explain higher amounts of Neandertal ancestry in East Asian than in European human populations.

@article{Kim2015SelectionAR,
  title={Selection and reduced population size cannot explain higher amounts of Neandertal ancestry in East Asian than in European human populations.},
  author={Bernard Youngsoo Kim and Kirk E. Lohmueller},
  journal={American journal of human genetics},
  year={2015},
  volume={96 3},
  pages={
          454-61
        }
}
It has been hypothesized that the greater proportion of Neandertal ancestry in East Asians than in Europeans is due to the fact that purifying selection is less effective at removing weakly deleterious Neandertal alleles from East Asian populations. Using simulations of a broad range of models of selection and demography, we have shown that this hypothesis cannot account for the higher proportion of Neandertal ancestry in East Asians than in Europeans. Instead, more complex demographic… CONTINUE READING
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