Selection and mutation for α Thalassemia in nonmalarial and malarial environments.

  title={Selection and mutation for α Thalassemia in nonmalarial and malarial environments.},
  author={Philip W Hedrick},
  journal={Annals of human genetics},
  volume={75 4},
α thalassemia is the result of the loss of one or both copies of the two human α globin genes. α thalassemia appears to be the most common monogenic disease in the world and is in high frequency where malaria is, or has been, endemic. In nonmalarial environments, α thalassemia is rare and its frequency can be explained by a balance of deletional mutation and purifying selection. In malarial environments, the loss of one or two copies of the four α globin genes in normal diploid genotypes… CONTINUE READING


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