Selection and micropropagation of high artemisinin producing clones of Artemisia annua L.

@article{Elhag1992SelectionAM,
  title={Selection and micropropagation of high artemisinin producing clones of Artemisia annua L.},
  author={H. M. Elhag and M. M. El-domiaty and Farouk S. El-Feraly and Jaber S. Mossa and Mahmoud M. El-Olemy},
  journal={Phytotherapy Research},
  year={1992},
  volume={6}
}
An in vitro micropropagation method has been used to clone Artemisia annua L. plants from axenic seedlings or field grown plants selected on the basis of morphological characteristics during the growing season. Clones were maintained in culture by continuous transfer every 4–6 weeks. The performance of the various clones in the field as well as their contents of artemisinin and related sesquiterpenes were compared with selected field grown plants. An internally standardized reverse‐phase HPLC… Expand
Isolation of high artemisinin-yielding clones of Artemisia annua☆
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The artemis inin profiles of the micropropagated progenies at vegetative, preflowering and full bloom stages indicated that while highest artemisinin accumulation occurred at full bloom stage, the art Artemisinin content at preflowered stage was positively correlated with that at full Bloom stage. Expand
In Vitro Micropropagation and Flowering in Artemisia annua
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Impact of plant growth regulators (PGRs) on callogenesis and artemisinin content in Artemisia annua L. plants
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Efficient Somatic Embryogenesis and Organogenesis of Self-Pollination Artemisia annua Progeny and Artemisinin Formation in Regenerated Plants
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Seasonal and Differential Sesquiterpene Accumulation in Artemisia annua Suggest Selection Based on Both Artemisinin and Dihydroartemisinic Acid may Increase Artemisinin in planta
TLDR
The data suggest that different chemotypes, high in ART and DHAA, have complementary pathways, while competing with AA, and that crossing plants high in Artemisinin andDHAA may generate hybrids with higher ART than currently available in commercial germplasms. Expand
Distinctive morphological characteristics contribute to the identification of Artemisia annua L. germplasms with high yield and high artemisinin content
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TLDR
In order to investigate the possibility of isolating greater amounts of the antimalarial compound artemisinin (quinghaosu), plants of ARTEMISIA ANNUA were cultivated and analysed at different stages of development, and two hormone-type growth regulators were tested on A. ANNUA strain 811. Expand
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TLDR
The genus Artemisia is one of the largest and is the most geographically distributed of the 102 genera in the Anthemideae tribe of the compositae family and efforts are being made to select high-content artemisinin plants from field-grown Artemisia plants, although the selection criteria presently used are not well defined. Expand
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Abstract Artemisinin (qinghaosu), a seco -sesquiterpene peroxide, is the clinically established antimalarial principle isolated from the leaves of the Chinese medicinal herb, Artemisia annua . RecentExpand
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TLDR
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Artemisinin, a potent antimalarial sesquiterpene endoperoxide, was converted via a photochemical route to its dehydro analogue, artemisitene
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