Selection and characterization of human respiratory syncytial virus escape mutants resistant to a polyclonal antiserum raised against the F protein

@article{Tom2012SelectionAC,
  title={Selection and characterization of human respiratory syncytial virus escape mutants resistant to a polyclonal antiserum raised against the F protein},
  author={Lorena Magal{\'i} Tom{\'e} and Sandra Frabasile and Claudia Candia and Alvaro Pittini and Natalia Farina and Jos{\'e} A Melero and Juan Arbiza},
  journal={Archives of Virology},
  year={2012},
  volume={157},
  pages={1071-1080}
}
A human respiratory syncytial virus (HRSV) neutralization escape mutant was obtained after 56 serial passages in the presence of a polyclonal antiserum raised against the F protein. Nucleotide sequence analysis of this escape mutant virus revealed two amino acid substitutions: Asn268Ile and Val533Met. When this virus was allowed to grow in the absence of the anti-F polyclonal serum, only the mutation Asn268Ile was stably maintained. Both the double and single escape mutant viruses lost… CONTINUE READING

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