Selection and characterization of human PCSK9 antibody from phage displayed antibody library.

@article{Cao2015SelectionAC,
  title={Selection and characterization of human PCSK9 antibody from phage displayed antibody library.},
  author={Yan Cao and H. -S. Yang and Xiaolong Zhou and Huiwen Mao and Tingting Gao and Zhigang Hu and Lingfeng He and Feiyan Pan and Zhigang Guo},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={463 4},
  pages={712-8}
}
Proprotein convertase subtilisin/kexin type 9 (PCSK9), which involves in low-density lipoprotein cholesterol (LDL-C) metabolism by interacting with the LDL receptor, is considered as a potent therapeutic target for treating hypercholesterolemia. Here, a fab antibody phage display library was constructed and employed for bio-panning against recombinant PCSK9… CONTINUE READING