Selection and characterization of anti-NF-kappaB p65 RNA aptamers.

Abstract

NF-kappaB transcription factors include a group of five mammalian proteins that form hetero- or homodimers and regulate hundreds of target genes involved in acute inflammation, HIV-1 transcription activation, and resistance to cancer therapy. We previously used in vitro selection to develop a small RNA aptamer (anti-p50) that binds the DNA-binding domain of… (More)
DOI: 10.1261/rna.878908

Topics

  • Presentations referencing similar topics