Selection and characterization of Autographa californica multiple nucleopolyhedrovirus DNA polymerase mutations.

@article{Feng2012SelectionAC,
  title={Selection and characterization of Autographa californica multiple nucleopolyhedrovirus DNA polymerase mutations.},
  author={Guozhong Feng and David K. Thumbi and Jondavid G. de Jong and J. Jefferson Hodgson and Basil Arif and Daniel Doucet and Peter J. Krell},
  journal={Journal of virology},
  year={2012},
  volume={86 24},
  pages={
          13576-88
        }
}
Autographa californica multiple nucleopolyhedrovirus (AcMNPV) DNA polymerase (DNApol) is essential for viral DNA replication. AcMNPV mutants resistant to aphidicolin, a selective inhibitor of viral DNA replication, and abacavir, an efficacious nucleoside analogue with inhibitory activity against reverse transcriptase, were selected by the serial passage of the parental AcMNPV in the presence of increasing concentrations of aphidicolin or abacavir. These drug-resistant mutants had either a… CONTINUE READING
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