Selection and characterization of Affibody ligands binding to Alzheimer amyloid beta peptides.

@article{Grnwall2007SelectionAC,
  title={Selection and characterization of Affibody ligands binding to Alzheimer amyloid beta peptides.},
  author={Caroline Gr{\"o}nwall and Andreas Jonsson and Sara Lindstr{\"o}m and Elin Gunneriusson and Stefan St{\aa}hl and Nina Herne},
  journal={Journal of biotechnology},
  year={2007},
  volume={128 1},
  pages={162-83}
}
Affibody (Affibody) ligands specific for human amyloid beta (Abeta) peptides (40 or 42 amino acid residues in size), involved in the progress of Alzheimer's disease, were selected by phage display technology from a combinatorial protein library based on the 58-amino acid residue staphylococcal protein A-derived Z domain. Post-selection screening of 384 randomly picked clones, out of which 192 clones were subjected to DNA sequencing and clustering, resulted in the identification of 16 Affibody… CONTINUE READING

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