Selection and altered properties of brain-colonising metastatic melanoma

@article{Brunson1978SelectionAA,
  title={Selection and altered properties of brain-colonising metastatic melanoma},
  author={Kenneth W. Brunson and G. F. Beattie and Garth L. Nicolson},
  journal={Nature},
  year={1978},
  volume={272},
  pages={543-545}
}
Two of the least understood properties of malignant tumour cells are their abilities to invade surrounding normal tissues and to escape to form secondary tumours (metastases) at near and distant sites1–3. Distant metastases can arise when invading malignant cells penetrate into and are disseminated in the lymphatics, coelomic cavities or blood circulatory system. The mere presence of tumour cells in the blood does not necessarily indicate that distant metastatic disease will follow4, for most… CONTINUE READING
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