Selection Conflicts, Gene Expression, and Codon Usage Trends in Yeast

@article{Kliman2003SelectionCG,
  title={Selection Conflicts, Gene Expression, and Codon Usage Trends in Yeast},
  author={Richard M. Kliman and Naheelah Irving and Mar{\'i}a Vicente Santiago},
  journal={Journal of Molecular Evolution},
  year={2003},
  volume={57},
  pages={98-109}
}
Synonymous codon usage in yeast appears to be influenced by natural selection on gene expression, as well as regional variation in compositional bias. Because of the large number of potential targets of selection (i.e., most of the codons in the genome) and presumed small selection coefficients, codon usage is an excellent model for studying factors that limit the effectiveness of selection. We use factor analysis to identify major trends in codon usage for 5836 genes in Saccharomyces… CONTINUE READING

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