Selection Conflicts, Gene Expression, and Codon Usage Trends in Yeast

  title={Selection Conflicts, Gene Expression, and Codon Usage Trends in Yeast},
  author={Richard M. Kliman and Naheelah Irving and Mar{\'i}a Vicente Santiago},
  journal={Journal of Molecular Evolution},
Synonymous codon usage in yeast appears to be influenced by natural selection on gene expression, as well as regional variation in compositional bias. Because of the large number of potential targets of selection (i.e., most of the codons in the genome) and presumed small selection coefficients, codon usage is an excellent model for studying factors that limit the effectiveness of selection. We use factor analysis to identify major trends in codon usage for 5836 genes in Saccharomyces… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 46 references

Codon usage and tRNA content in unicellular and multicellular organisms.

Molecular biology and evolution • 1985
View 7 Excerpts
Highly Influenced

The genome sequence of Drosophila melanogaster.

Science • 2000
View 7 Excerpts
Highly Influenced

Codon selection in yeast.

The Journal of biological chemistry • 1982
View 5 Excerpts
Highly Influenced

Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America • 2000
View 3 Excerpts
Highly Influenced

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