Selection, recombination, and G----A hypermutation of human immunodeficiency virus type 1 genomes.

@article{Vartanian1991SelectionRA,
  title={Selection, recombination, and G----A hypermutation of human immunodeficiency virus type 1 genomes.},
  author={J P Vartanian and Andreas Meyerhans and Birgitta {\AA}sj{\"o} and Simon Wain-Hobson},
  journal={Journal of virology},
  year={1991},
  volume={65 4},
  pages={1779-88}
}
Human immunodeficiency virus type 1 (HIV-1) isolates are genetically so heterogeneous that they must be described in terms of populations of related but distinct genomes called quasispecies. A recent study of the influence of ex vivo culturing on HIV-1 quasispecies demonstrated that usually low-abundance genomes outgrew the more prominent forms. Here it is shown that multiple passages of an HIV-1 isolate on peripheral blood mononuclear cells resulted in the outgrowth of very minor forms. A… CONTINUE READING