Selection, epistasis, and parent-of-origin effects on deleterious mutations across environments in Drosophila melanogaster.

@article{Wang2009SelectionEA,
  title={Selection, epistasis, and parent-of-origin effects on deleterious mutations across environments in Drosophila melanogaster.},
  author={Alethea D Wang and Nathaniel P Sharp and Christine C Spencer and Katherine Tedman-Aucoin and Aneil F. Agrawal},
  journal={The American naturalist},
  year={2009},
  volume={174 6},
  pages={863-74}
}
Understanding the nature of selection against deleterious alleles is central to determining how populations are affected by the constant influx of new mutations. Important progress has been made in estimating basic attributes of the distribution of selection coefficients and gene interaction effects (epistasis). Although most aspects of selection are likely to be context dependent, little is known about the effect of stress on selection and epistasis at the level of individual genes, especially… CONTINUE READING