Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein

Abstract

CEA is a tumor-associated antigen abundantly expressed on several cancer types, including those naturally refractory to chemotherapy. The selection and characterization of human anti-CEA single-chain antibody fragments (scFv) is a first step toward the construction of new anticancer monoclonal antibodies designed for optimal blood clearance and tumor… (More)
DOI: 10.1186/1471-2407-6-41

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