Selectins and selectin ligands in extravasation of cancer cells and organ selectivity of metastasis

@article{Gout2007SelectinsAS,
  title={Selectins and selectin ligands in extravasation of cancer cells and organ selectivity of metastasis},
  author={St{\'e}phanie Gout and Pierre-Luc Gilbert Tremblay and Jacques Huot},
  journal={Clinical & Experimental Metastasis},
  year={2007},
  volume={25},
  pages={335-344}
}
Metastatic spreading is a dreadful complication of neoplastic diseases that is responsible for most deaths due to cancer. It consists in the formation of secondary neoplasms from cancer cells that have detached from the primary site. The formation of these secondary sites is not random and several clinical observations indicate that the metastatic colonization exhibits organ selectivity. This organ tropism relies mostly on the complementary adhesive interactions between the cancer cells and… CONTINUE READING