Selecting optimal antisense reagents.

@article{Sohail2000SelectingOA,
  title={Selecting optimal antisense reagents.},
  author={Muhammad Sohail and E. M. Southern},
  journal={Advanced drug delivery reviews},
  year={2000},
  volume={44 1},
  pages={23-34}
}
Selection of the appropriate target site is crucial to the success of an antisense experiment. The selection is difficult because RNAs fold to form secondary structures, rendering most of the molecule inaccessible to intermolecular base pairing with complementary nucleic acids. Conventional approaches, such as selection by 'sequence-walking' or computer-assisted design, have not brought significant success. Several empirical selection methods have been reported, a number of which are summarised… CONTINUE READING

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