Selecting models of nucleotide substitution: an application to human immunodeficiency virus 1 (HIV-1).

@article{Posada2001SelectingMO,
  title={Selecting models of nucleotide substitution: an application to human immunodeficiency virus 1 (HIV-1).},
  author={David Posada and Keith A. Crandall},
  journal={Molecular biology and evolution},
  year={2001},
  volume={18 6},
  pages={897-906}
}
The blind use of models of nucleotide substitution in evolutionary analyses is a common practice in the viral community. Typically, a simple model of evolution like the Kimura two-parameter model is used for estimating genetic distances and phylogenies, either because other authors have used it or because it is the default in various phylogenetic packages. Using two statistical approaches to model fitting, hierarchical likelihood ratio tests and the Akaike information criterion, we show that… CONTINUE READING
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