Selecting immunohistochemical cut-off scores for novel biomarkers of progression and survival in colorectal cancer.

@article{Zlobec2007SelectingIC,
  title={Selecting immunohistochemical cut-off scores for novel biomarkers of progression and survival in colorectal cancer.},
  author={Inti Zlobec and Russell Steele and Luigi Maria Terracciano and Jeremy R. Jass and Alessandro Lugli},
  journal={Journal of clinical pathology},
  year={2007},
  volume={60 10},
  pages={1112-6}
}
BACKGROUND Cut-off scores for determining positivity of biomarkers detected by immunohistochemistry are often set arbitrarily and vary between reports. AIMS To evaluate the performance of receiver operating characteristic (ROC) curve analysis in determining clinically important cut-off scores for a novel tumour marker, the receptor for hyaluronic acid mediated motility (RHAMM), and show the reproducibility of the selected cut-off scores in 1197 mismatch-repair (MMR) proficient colorectal… CONTINUE READING

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