Selecting effective antisense reagents on combinatorial oligonucleotide arrays

Abstract

An array of 1,938 oligodeoxynucleotides (ONs) ranging in length from monomers to 17-mers was fabricated on the surface of a glass plate and used to measure the potential of oligonucleotide for heteroduplex formation with rabbit β-globin mRNA. The oligonucleotides were complementary to the first 122 bases of mRNA comprising the 5′ UTR and bases 1 to 69 of… (More)
DOI: 10.1038/nbt0697-537

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