Selecting an Antidepressant for Use in a Patient with Epilepsy

@article{Curran1998SelectingAA,
  title={Selecting an Antidepressant for Use in a Patient with Epilepsy},
  author={Stephen A Curran and Karel E. De Pauw},
  journal={Drug Safety},
  year={1998},
  volume={18},
  pages={125-133}
}
SummaryDepression is a common and disabling condition and is especially disabling for patients who also have epilepsy. Antidepressants, particularly the tricyclic antidepressants are well known to be associated with seizure activity, but this is a very neglected area of research. Most of the data on the proconvulsive effects of antidepressants come from either work in animal models or from research into the effects of antidepressants in overdose. Both of these situations may tell us little… Expand
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References

SHOWING 1-10 OF 47 REFERENCES
Which is the safest antidepressant to use in epilepsy
TLDR
There have been no double-blind trials performed to determine differences between seizure rates for two drugs or between drug and control groups, and methodological problems become apparent when comparing the results of published studies available. Expand
Drug treatment of depression in medically ill patients.
  • H. Series
  • Medicine
  • Journal of psychosomatic research
  • 1992
TLDR
There is relatively little to choose between antidepressants in terms of efficacy (although the quantity and quality of these data vary), and it is therefore primarily the risks which should determine the choice of antidepressant, and these must be separately evaluated for each patient. Expand
Seizures associated with antidepressants: a review.
TLDR
Assessment of seizure risk in individuals involves consideration of predisposing factors, the antidepressant selected, and the bioavailability of the drug. Expand
Electroconvulsive Therapy as an Anticonvulsant
TLDR
The available data on the anticonvulsant effects of ECS are reviewed and a discussion of these findings and their mechanistic implications are begun. Expand
Clinical overview of serotonin re-uptake inhibitors
The SSRIs are a new class of effective antidepressant agents which have proven efficacy in a wide range of psychiatric applications. They are as effective as the tricyclic antidepressants and areExpand
Clinical overview of serotonin reuptake inhibitors.
TLDR
Serotonin reuptake inhibitors have not replaced the tricyclics, but are a useful addition to the variety of drugs currently used for the treatment of depression. Expand
The Incidence of Seizures during Tricyclic Antidepressant Drug Treatment in a Brain-Injured Population
TLDR
The incidence of seizures possibly precipitated by TCAs was examined retrospectively in a population of 68 severely brain-injured patients, all of whom were at high risk for the development of seizures. Expand
Seizures with neuroleptics and antidepressants.
TLDR
Available evidence suggests that molindone, fluphenazine, and haloperidol are among the least seizurogenic neuroleptics and that doxepin, monoamine oxidase inhibitors, or electroconvulsive therapy may be safest in treating the depressed patient at risk for seizures. Expand
Effect of doxepin on seizure frequency in depressed epileptic patients
TLDR
Comparison of mean monthly seizure frequency during equal blocks of time before and during treatment with doxepin in doses of 5 to 400 mg/ day demonstrated improved seizure control in 15, no change in 2, and increased seizures in 2 patients. Expand
Efficacy and tolerability of reboxetine compared with imipramine in a double-blind study in patients suffering from major depressive episodes
Abstract A 6-week, randomised, double-blind, multicentre study in 256 patients with a DSM-III-R diagnosis of major depression was carried out to compare the selective noradrenaline reuptake inhibitorExpand
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