Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers.

  title={Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers.},
  author={Sylvain Julien and Aleksandar Ivetic and Anita Grigoriadis and Ding Qize and Brian Burford and Daisy Sproviero and Gianfranco Picco and Cheryl E. Gillett and Suzanne L. Papp and Lana Schaffer and Andrew N J Tutt and Joyce Taylor-Papadimitriou and Sarah E. Pinder and Joy M. Burchell},
  journal={Cancer research},
  volume={71 24},
The glycome acts as an essential interface between cells and the surrounding microenvironment. However, changes in glycosylation occur in nearly all breast cancers, which can alter this interaction. Here, we report that profiles of glycosylation vary between ER-positive and ER-negative breast cancers. We found that genes involved in the synthesis of sialyl-Lewis x (sLe(x); FUT3, FUT4, and ST3GAL6) are significantly increased in estrogen receptor alpha-negative (ER-negative) tumors compared with… CONTINUE READING


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