Selectin inhibitors: a patent review.

@article{Bedard2010SelectinIA,
  title={Selectin inhibitors: a patent review.},
  author={Patricia W Bedard and Neelu Kaila},
  journal={Expert opinion on therapeutic patents},
  year={2010},
  volume={20 6},
  pages={781-93}
}
IMPORTANCE OF THE FIELD Selectins play a significant and well-documented role in inflammation and immune response. They initiate tethering and rolling of blood borne leukocytes leading to their activation, adhesion and subsequent extravazation into tissues. This is important for healthy immune response and tissue repair. However, dysregulation of selectins leads to exacerbation of disease. Atherosclerosis, restenosis, deep venous thrombosis and tumor metastasis are just a few of the diseases in… CONTINUE READING
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