Selectin inhibitor bimosiamose prolongs survival of kidney allografts by reduction in intragraft production of cytokines and chemokines.

Abstract

Binding of the P-, L-, and E-selectins to sialyl Lewis(x) (sLe(x)) retards circulating leukocytes, thereby facilitating their attachment to the blood vessels of allografts. Whether the selectin inhibitor bimosiamose (BIMO; C(46)H(54)O(16) . 0.25 H(2)O [867.4 molecular weight]) inhibits the rejection process of kidney allografts in a rat model was examined… (More)

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Cite this paper

@article{Langer2004SelectinIB, title={Selectin inhibitor bimosiamose prolongs survival of kidney allografts by reduction in intragraft production of cytokines and chemokines.}, author={Robert Langer and Mouer Wang and Stanislaw M. Stepkowski and Wayne W. Hancock and Rongxiang Han and Ping Li and Lily Feng and Robert A. Kirken and Kurt L. Berens and Brian Dupr{\'e} and Hemangshu Podder and Richard Dixon and Barry D. Kahan}, journal={Journal of the American Society of Nephrology : JASN}, year={2004}, volume={15 11}, pages={2893-901} }