Selectin Ligands Sialyl-Lewis a and Sialyl-Lewis x in Gastrointestinal Cancers

  title={Selectin Ligands Sialyl-Lewis a and Sialyl-Lewis x in Gastrointestinal Cancers},
  author={Marco Trinchera and Adele Aronica and Fabio Dall’olio},
The tetrasaccharide structures Siaα2,3Galβ1,3(Fucα1,4)GlcNAc and Siaα2,3Galβ1,4(Fucα1,3)GlcNAc constitute the epitopes of the carbohydrate antigens sialyl-Lewis a (sLea) and sialyl-Lewis x (sLex), respectively, and are the minimal requirement for selectin binding to their counter-receptors. Interaction of sLex expressed on the cell surface of leucocytes with E-selectin on endothelial cells allows their arrest and promotes their extravasation. Similarly, the rolling of cancer cells ectopically… CONTINUE READING
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Molecular Cloning of the Human b1,4 N-Acetylgalactosaminyltransferase Responsible for the Biosynthesis of the Sda Histo-Blood Group Antigen: The Sequence Predicts a Very Long Cytoplasmic Domain

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