Selected contribution: time course and heterogeneity of contractile responses in cultured human airway smooth muscle cells.

@article{Fabry2001SelectedCT,
  title={Selected contribution: time course and heterogeneity of contractile responses in cultured human airway smooth muscle cells.},
  author={Ben Fabry and Geoffrey N. Maksym and Stephanie A. Shore and Paul E Moore and Reynold A Panettieri and James P. Butler and Jeffrey J. Fredberg},
  journal={Journal of applied physiology},
  year={2001},
  volume={91 2},
  pages={986-94}
}
We measured the time course and heterogeneity of responses to contractile and relaxing agonists in individual human airway smooth muscle (HASM) cells in culture. To this end, we developed a microrheometer based on magnetic twisting cytometry adapted with a novel optical detection system. Ferromagnetic beads (4.5 microm) coated with Arg-Gly-Asp peptide were bound to integrins on the cell surface. The beads were twisted in a sinusoidally varying magnetic field at 0.75 Hz. Oscillatory bead… CONTINUE READING

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