Selected contribution: Time-dependent hypoxic respiratory responses in female rats are influenced by age and by the estrus cycle.

@article{Zabka2001SelectedCT,
  title={Selected contribution: Time-dependent hypoxic respiratory responses in female rats are influenced by age and by the estrus cycle.},
  author={A G Zabka and Mary Behan and Gordon S Mitchell},
  journal={Journal of applied physiology},
  year={2001},
  volume={91 6},
  pages={
          2831-8
        }
}
Age affects time-dependent respiratory responses to episodic hypoxia in male rats, particularly long-term facilitation (LTF), a serotonin-dependent respiratory "memory" [Zabka AG, Behan M, and Mitchell GS, J Physiol (Lond) 531: 509, 2001]. Because age and gender influence serotonergic function, we tested the hypotheses that the short-term hypoxic response (STHR), posthypoxia frequency decline (PHFD) and LTF of phrenic and hypoglossal (XII) motor output change with age and stage of the estrus… 
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Selected contribution: chronic intermittent hypoxia enhances respiratory long-term facilitation in geriatric female rats.
TLDR
Chronic intermittent hypoxia (CIH) enhances LTF (41) and it is predicted that CIH would restore LTF in geriatric female rats, which was smaller than previously reported for middle-aged rats but comparable to that in young female rats.
Development of ventilatory long-term facilitation is dependent on estrous cycle stage in adult female rats
Hypoxic and hypercapnic ventilatory responses in aging male vs. aging female rats.
TLDR
Assessment of the effects of sex and age on the hypoxic (HVR) and the hypercapnic ventilatory responses (HCVR) of awake rats relative to systemic hormone levels found no age-related changes in the HVR or HCVR.
Conversion from testosterone to oestradiol is required to modulate respiratory long‐term facilitation in male rats
TLDR
It is concluded that the conversion of testosterone to oestradiol modulates phrenic and XII LTF in male F344 rats.
Differential expression of respiratory long-term facilitation among inbred rat strains
Gender considerations in ventilatory and metabolic development in rats: Special emphasis on the critical period
Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult rats.
TLDR
It is concluded that early postnatal CIH modifies normoxic and hypoxic ventilatory and phrenic responses that persist at 1 mo after cessation of CIH and markedly differ from previously reported increased neural plasticity changes induced by CIH in adult rats.
Intermittent hypoxia induces phrenic long-term facilitation in carotid-denervated rats.
TLDR
The data suggest that hypoxia per se initiates LTF independently from carotid chemoafferent neuron activation, perhaps through direct central nervous system effects.
Differences in time-dependent hypoxic phrenic responses among inbred rat strains.
TLDR
Genetic differences exist in the time domains of the hypoxic response, and these are differentially expressed in hypoglossal and phrenic nerves.
Ovariectomy at 3 or 10 weeks of age does not affect the ventilatory response to hypoxia in adult rats
TLDR
It is suggested that ovariectomy at either a young or at an adult age is insufficient to completely suppress circulating hormones and disrupt the regulation of ventilation.
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References

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TLDR
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TLDR
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