Selected approaches for increasing HIV DNA vaccine immunogenicity in vivo.

@article{Hutnick2011SelectedAF,
  title={Selected approaches for increasing HIV DNA vaccine immunogenicity in vivo.},
  author={Natalie A. Hutnick and Devin J F Myles and Chaoran Billie Bian and Karuppiah Muthumani and David B. Weiner},
  journal={Current opinion in virology},
  year={2011},
  volume={1 4},
  pages={233-40}
}
The safety, stability, and ability for repeat homologous vaccination makes the DNA vaccine platform an excellent candidate for an effective HIV-1 vaccine. However, the immunogenicity of early DNA vaccines did not translate from small animal models into larger non-human primates and was markedly lower than viral vectors. In addition to improvements to the DNA vector itself, delivery with electroporation, the inclusion of molecular adjuvants, and heterologous prime-boost strategies have… CONTINUE READING
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Heterologous prime/boost immunizations of rhesus monkeys Current Opinion in Virology

  • S Santra, Y Sun, +7 authors GJ Nabel
  • Vaccine
  • 2011
1 Excerpt

SIV DNA vaccination with EP induced similar or better cellular immunity when compared with the Merck Ad 5 SIV vaccine in rhesus macaques

  • T Hanke, VC Neumann, +4 authors A McMichael
  • Current Opinion in Virology
  • 2011

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