Selected amino acids, dipeptides and arylalkylamine derivatives do not act as allosteric modulators at GABAB receptors.

@article{Urwyler2004SelectedAA,
  title={Selected amino acids, dipeptides and arylalkylamine derivatives do not act as allosteric modulators at GABAB receptors.},
  author={Stephan Urwyler and Tina Gjoni and Klemens Kaupmann and Mario F. Pozza and Johannes Mosbacher},
  journal={European journal of pharmacology},
  year={2004},
  volume={483 2-3},
  pages={
          147-53
        }
}
Based on recent reports describing enhancing actions of arylalkylamines (fendiline [N-(3,3-diphenylpropyl)-alpha-methylbenzylamine] and prenylamine [N-(3,3-diphenylpropyl)-alpha-methylphenethylamine]), amino acids (L-phenylalanine, L-leucine and L-isoleucine), and dipeptides (L-Phe-Phe and L-Phe-Leu) on baclofen-induced responses in cortical slices, we have examined whether these compounds might act as positive allosteric modulators at GABA(B) receptors. Unlike the previously described… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Endogenous allosteric modulators of G protein-coupled receptors.

  • The Journal of pharmacology and experimental therapeutics
  • 2015
VIEW 1 EXCERPT
CITES BACKGROUND