Selected Stro-1-enriched bone marrow stromal cells display a major suppressive effect on lymphocyte proliferation.

@article{Nasef2009SelectedSB,
  title={Selected Stro-1-enriched bone marrow stromal cells display a major suppressive effect on lymphocyte proliferation.},
  author={Aisha Nasef and Yu Zhi Zhang and Christelle Mazurier and Sandrine Bouchet and Morad Bensidhoum and Sabine François and N. C. Gorin and Marc Lopez and D. Thierry and Lo{\"i}c Fouillard and Alain A Chapel},
  journal={International journal of laboratory hematology},
  year={2009},
  volume={31 1},
  pages={9-19}
}
Mesenchymal stem cells (MSCs) have an immunosuppressive effect and can inhibit the proliferation of alloreactive T cells in vitro and in vivo. Cotransplantation of MSCs and hematopoietic stem cells (HSCs) from HLA-identical siblings has been shown to reduce the incidence of acute graft-vs.-host disease. MSCs are heterogeneous and data on the inhibitory effects of different MSC subsets are lacking. The antigen Stro1 is a marker for a pure primitive MSC subset. We investigated whether Stro-1… CONTINUE READING

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