Selected Haematological and Biochemical Parameters of Blood in Rats After Subchronic Administration of Vanadium and/or Magnesium in Drinking Water

  title={Selected Haematological and Biochemical Parameters of Blood in Rats After Subchronic Administration of Vanadium and/or Magnesium in Drinking Water},
  author={Agnieszka Ścibior and Halina Zaporowska and Jarosław Ostrowski},
  journal={Archives of Environmental Contamination and Toxicology},
The purpose of these studies was to evaluate the effect of selected vanadium and magnesium doses on certain haematological and biochemical blood parameters in rats. Outbred 2-month-old, albino male Wistar rats received for a period of 6 weeks, as a sole drinking liquid, the following water solutions: group II, sodium metavanadate (SMV) at a concentration of 0.125 mg V/mL; group III, magnesium sulphate (MS) at a concentration of 0.06 mg Mg/mL; and group IV, SMV-MS solution at the same… 
Lipid peroxidation in the liver of rats treated with V and/or Mg in drinking water
The three‐way ANOVA revealed that the changes in LPO induced by in vitro treatment of liver supernatants with exogenous Fe or V or Mg were a consequence of independent action of those metals and they also resulted from the interactions between Feexog and Vend and between Vend and Vexog.
Effects of combined vanadate and magnesium treatment on erythrocyte antioxidant defence system in rats.
Aggravation by vanadium of magnesium deficiency in STZ-induced diabetic rats.
Although treatment with 3 mg V/day normalised the glycaemia, the hypomagnesaemia and tissue depletion of Mg seen in the diabetic rats, caused by the treatment with V, could have partially contributed to the fact that V did not normalise other serum parameters altered by the diabetes.
Bioavailability, tissue distribution and hypoglycaemic effect of vanadium in magnesium-deficient rats.
Interactions between magnesium and vanadium in the digestive and renal systems are shown and treatment with vanadium to magnesium-deficient rats corrected many of the alterations that had been generated by the magnesium deficiency.
Changes in the antioxidant defence and in selenium concentration in tissues of vanadium exposed rats.
It is concluded that healthy rats are more sensitive than diabetic ones to the effects of V, and should be taken into account for populations that are particularly exposed to V for environmental reasons, and/or that consume V as a nutritional supplement.
The influence of combined magnesium and vanadate administration on the level of some elements in selected rat organs: V-Mg interactions and the role of iron-essential protein (DMT-1) in the mechanism underlying altered tissues iron level.
The SMV-induced fall in total iron binding capacity (TIBC), reported previously, and its correlations with the hepatic, splenic, and cerebral Fe levels allow us to suggest that diminished TIBC could be partly involved in the mechanism(s) responsible for the dramatic redistribution of Fe in those tissues.
Effects of vanadium (V) and magnesium (Mg) on rat bone tissue: mineral status and micromorphology. Consequences of V-Mg interactions.
The extent to which the 12 week separate and combined administration of vanadium and magnesium affects bone mineral status and micromorphology as well as the alkaline phosphatase (ALP) activity in femoral diaphysis (FD) was examined in male rats was examined.


Lack of haematological effect of oral vanadium treatment in rats.
It is concluded that ammonium metavanadate, vanadyl sulphate, and bis(maltolato) oxovanadium (i.v.), at least at the doses and at the duration of treatment employed, do not produce significant haematological toxicity in rats.
Effect of chronic vanadium administration in drinking water to rats
Hematological examination and biochemical analyses demonstrated a decrease of l-ascorbic acid levels in the plasma and erythrocytes of animals drinking the AMV solutions and a distinct tendency for the malonyldialdehyde level to increase in the blood.
Effect of magnesium supplementation and training on magnesium tissue distribution in rats
It is concluded that Mg supplementation improves bone and serum Mg levels, but this does not affect Mg status in soft tissues.
Effect of age on vanadium nephrotoxicity in rats.
Lipid peroxidation and antioxidant enzymes in vanadate-treated rats.
Lower doses of vanadate in combination with trigonella restore altered carbohydrate metabolism and antioxidant status in alloxan-diabetic rats.
One-year treatment of non-diabetic and streptozotocin-diabetic rats with vanadyl sulphate did not alter blood pressure or haematological indices.
It was found that prolonged treatment of either nondiabetic or streptozotocin-diabetic rats with vanadyl sulphate did not cause significant changes in the parameters observed but significantly alleviated the occurrence of bradycardia and the decreased leukocyte count in the peripheral blood in streptoregic animals.